The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …

It has recently become apparent that RNA, itself the product of transcription, is a major
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …

The landmark 1969 discovery of nuclear RNA polymerases I, II and III in diverse eukaryotes
represented a major turning point in the field that, with subsequent elucidation of the distinct …

The 7S particle of Xenopus laevis oocytes contains 5S RNA and a 40‐K protein which is
required for 5S RNA transcription in vitro. Proteolytic digestion of the protein in the particle …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

A 30-amino-acid segment of C/EBP, a newly discovered enhancer binding protein, shares
notable sequence similarity with a segment of the cellular Myc transforming protein. Display …

▪ Abstract Cys2His2 zinc fingers are one of the most common DNA-binding motifs found in
eukaryotic transcription factors. These proteins typically contain several fingers that make …

Contemporary views on the structure and function of chromatin are presented and the
history of the development of these ideas as well as the nature of the nucleic acid and …

The identification of ultraconserved noncoding sequences in vertebrates has been
associated with developmental regulators and DNA-binding proteins. One of the first of …

Heterokaryons provide a model system in which to examine how tissue-specific phenotypes
arise and are maintained. When muscle cells are fused with nonmuscle cells, muscle gene …