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A biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria
With the hope that disease-modifying treatments could target the molecular basis of
Parkinson's disease, even before the onset of symptoms, we propose a biologically based …
Parkinson's disease, even before the onset of symptoms, we propose a biologically based …
Genetics and pathogenesis of Parkinson's syndrome
Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
Inflammation and immune dysfunction in Parkinson disease
Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …
organs as well as the central nervous system and involves a fundamental role of …
Challenges in the diagnosis of Parkinson's disease
Parkinson's disease is the second most common neurodegenerative disease and its
prevalence has been projected to double over the next 30 years. An accurate diagnosis of …
prevalence has been projected to double over the next 30 years. An accurate diagnosis of …
Parkinson's disease
Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …
Role of dopamine in the pathophysiology of Parkinson's disease
A pathological feature of Parkinson's disease (PD) is the progressive loss of dopaminergic
neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD …
neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD …
Neuropathology and molecular diagnosis of Synucleinopathies
Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …
Parkinson's disease: etiopathogenesis and treatment
J Jankovic, EK Tan - Journal of Neurology, Neurosurgery & Psychiatry, 2020 - jnnp.bmj.com
The concept of 'idiopathic'Parkinson's disease (PD) as a single entity has been challenged
with the identification of several clinical subtypes, pathogenic genes and putative causative …
with the identification of several clinical subtypes, pathogenic genes and putative causative …
Progress towards therapies for disease modification in Parkinson's disease
The development of interventions to slow or halt the progression of Parkinson's disease
remains a priority for patients and researchers alike. To date, no agents have been shown to …
remains a priority for patients and researchers alike. To date, no agents have been shown to …
Ferroptosis in Parkinson's disease: molecular mechanisms and therapeutic potential
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …