Genome assembly in the telomere-to-telomere era

H Li, R Durbin - Nature Reviews Genetics, 2024 - nature.com
Genome sequences largely determine the biology and encode the history of an organism,
and de novo assembly—the process of reconstructing the genome sequence of an organism …

Repeat and haplotype aware error correction in nanopore sequencing reads with DeChat

Y Liu, Y Li, E Chen, J Xu, W Zhang, X Zeng… - Communications …, 2024 - nature.com
Error self-correction is crucial for analyzing long-read sequencing data, but existing methods
often struggle with noisy data or are tailored to technologies like PacBio HiFi. There is a gap …

Deciphering Complex Regions within the Human Genome and Unraveling Their Critical Biomedical Regulatory Functions

D Du, M Li, C Zhu, X Li, F Wu, W Zhang, X Cheng… - 2024 - researchsquare.com
Background: Nuclear genomic DNA plays a crucial role in individual development and
phenotype determination. The genetic landscape within populations exhibits significant …