Germ cells are the only cells in the body capable of giving rise to a new organism, and this
totipotency hinges on their ability to assemble membraneless germ granules. These …

The PIWI-interacting RNA (piRNA) pathway is a conserved defense system that protects the
genome integrity of the animal germline from deleterious transposable elements. Targets of …

Biomolecular condensates organize biochemical processes at the subcellular level and can
provide spatiotemporal regulation within a cell. Among these, ribonucleoprotein (RNP) …

The characterization of protein-protein interactions (PPIs) is fundamental to the
understanding of biochemical processes. Many methods have been established to identify …

Germ granules are hallmarks of all germ cells. Early ultrastructural studies in Drosophila first
described these membraneless granules in the oocyte and early embryo as filled with …

RNA granules are ubiquitous. Composed of RNA-binding proteins and RNAs, they provide
functional compartmentalization within cells. They are inextricably linked with RNA biology …

Summary mRNAs enriched in membraneless condensates provide functional
compartmentalization within cells. The mechanisms that recruit transcripts to condensates …

During Drosophila oogenesis, the Oskar (OSK) RNA binding protein (RBP) determines the
amount of germ plasm that assembles at the posterior pole of the oocyte. Here, we identify …

Germ granules are the hallmark of all germ cells. These membrane-less, electron-dense
structures were first observed over 100 years ago. Today, their role in regulating and …

Drosophila Smaug and its orthologs comprise a family of mRNA repressor proteins that
exhibit various functions during animal development. Smaug proteins contain a …