Prognostic neurobiomarkers in neonatal encephalopathy

G Wassink, S Harrison, S Dhillon, L Bennet… - Developmental …, 2022‏ - karger.com
Therapeutic hypothermia (TH) is now a standard treatment for infants with moderate-to-
severe neonatal encephalopathy (NE), and improves brain damage on neuroimaging and …

Physiological CTG categorization in types of hypoxia compared with MRI and neurodevelopmental outcome in infants with HIE

S Pereira, R Patel, A Zaima, K Tvarozkova… - The Journal of …, 2022‏ - Taylor & Francis
Background Commonly used methods of CTG classification do not reliably predict neonatal
hypoxic-ischemic encephalopathy (HIE). Objective To examine whether a relationship exists …

Magnetic resonance imaging diagnosis of causes of cerebral palsy in a develo** country: A database of South African children

MM Elsingergy, F Worede, S Venkatakrishna… - South African Medical …, 2021‏ - ajol.info
Background. Cerebral palsy (CP) is a common worldwide disabling disorder. However, data
about prevalence and causes of CP in develo** countries are deficient because of high …

Imaging of hypoxic-ischemic injury (in the era of cooling)

JA Gadde, AC Pardo, CS Bregman… - Clinics in …, 2022‏ - perinatology.theclinics.com
Hypoxic-ischemic injury (HII) is a major worldwide contributor of term neonatal mortality and
long-term morbidity in high, middle, and low-income countries. HII occurs in 2 per 1000 live …

Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy

V Ponnusamy, RTH Ip, MAEK Mohamed… - Communications …, 2021‏ - nature.com
Despite increasing knowledge on microRNAs, their role in the pathogenesis of neonatal
encephalopathy remains to be elucidated. Herein, we identify let-7b-5p as a significant …

Declining prevalence of cerebral palsy in children born at term in Denmark

ML Larsen, G Rackauskaite, G Greisen… - … Medicine & Child …, 2022‏ - Wiley Online Library
Aim To investigate reasons for the declining prevalence of cerebral palsy (CP) in children
born at term in Denmark by evaluating obstetric and neonatal factors associated with CP …

Neonatal brain MRI and short-term outcomes after acute provoked seizures

Y Li, A Scheffler, AJ Barkovich, T Chang, CJ Chu… - Journal of …, 2023‏ - nature.com
Objective We investigated how diagnosis and injury location on neonatal brain MRI
following onset of acute provoked seizures was associated with short term outcome. Study …

Long-chain omega-3 polyunsaturated fatty acids are reduced in neonates with substantial brain injury undergoing therapeutic hypothermia after hypoxic–ischemic …

SC Dyall, I Nessel, JA Sharpe, PK Yip… - Frontiers in …, 2023‏ - frontiersin.org
Hypoxic–ischemic encephalopathy (HIE) is a major cause of neonatal morbidity and
mortality. Although therapeutic hypothermia is an effective treatment, substantial chronic …

Raised plasma neurofilament light protein levels after rewarming are associated with adverse neurodevelopmental outcomes in newborns after therapeutic …

DK Shah, PK Yip, A Barlas, P Tharmapoopathy… - Frontiers in …, 2020‏ - frontiersin.org
Aim: To determine the predictive value of plasma neurofilament light protein (NfL) as a
prognostic marker for outcomes in babies who have undergone therapeutic hypothermia …

[HTML][HTML] Newborns with Favourable Outcomes after Perinatal Asphyxia Have Upregulated Glucose Metabolism-Related Proteins in Plasma

PK Yip, M Bremang, I Pike, V Ponnusamy… - Biomolecules, 2023‏ - mdpi.com
Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality
globally. Although mild therapeutic hypothermia (TH) may improve outcomes in selected …