Mutant p53 in cancer: from molecular mechanism to therapeutic modulation
X Chen, T Zhang, W Su, Z Dou, D Zhao, X **… - Cell Death & …, 2022 - nature.com
TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …
Cisplatin: mode of cytotoxic action and molecular basis of resistance
ZH Siddik - Oncogene, 2003 - nature.com
Cisplatin is one of the most potent antitumor agents known, displaying clinical activity
against a wide variety of solid tumors. Its cytotoxic mode of action is mediated by its …
against a wide variety of solid tumors. Its cytotoxic mode of action is mediated by its …
Molecular mechanisms of cisplatin resistance
Platinum-based drugs, and in particular cis-diamminedichloroplatinum (II)(best known as
cisplatin), are employed for the treatment of a wide array of solid malignancies, including …
cisplatin), are employed for the treatment of a wide array of solid malignancies, including …
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
Metabolic reprogramming has been proposed to be a hallmark of cancer, yet a systematic
characterization of the metabolic pathways active in transformed cells is currently lacking …
characterization of the metabolic pathways active in transformed cells is currently lacking …
Molecular mechanisms of drug resistance
DB Longley, PG Johnston - The Journal of Pathology: A Journal …, 2005 - Wiley Online Library
Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …
The role of p53 in cancer drug resistance and targeted chemotherapy
Cancer has long been a grievous disease complicated by innumerable players aggravating
its cure. Many clinical studies demonstrated the prognostic relevance of the tumor …
its cure. Many clinical studies demonstrated the prognostic relevance of the tumor …
Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
Drug sensitivity and resistance are conventionally quantified by IC50 or E max values, but
these metrics are highly sensitive to the number of divisions taking place over the course of …
these metrics are highly sensitive to the number of divisions taking place over the course of …
Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer
Breast cancer is the most frequently diagnosed cancer in women and one of the leading
causes of cancer death for women. Worldwide, over 1.3 million cases of invasive breast …
causes of cancer death for women. Worldwide, over 1.3 million cases of invasive breast …
Systems biology of cisplatin resistance: past, present and future
The platinum derivative cis-diamminedichloroplatinum (II), best known as cisplatin, is
currently employed for the clinical management of patients affected by testicular, ovarian …
currently employed for the clinical management of patients affected by testicular, ovarian …
Cancer cell lines are useful model systems for medical research
Cell lines are in vitro model systems that are widely used in different fields of medical
research, especially basic cancer research and drug discovery. Their usefulness is primarily …
research, especially basic cancer research and drug discovery. Their usefulness is primarily …