Single-target versus multi-target drugs versus combinations of drugs with multiple targets: preclinical and clinical evidence for the treatment or prevention of epilepsy
W Löscher - Frontiers in pharmacology, 2021 - frontiersin.org
Rationally designed multi-target drugs (also termed multimodal drugs, network therapeutics,
or designed multiple ligands) have emerged as an attractive drug discovery paradigm in the …
or designed multiple ligands) have emerged as an attractive drug discovery paradigm in the …
Is there a biochemical basis for purinergic P2X3 and P2X4 receptor antagonists to be considered as anti-seizure medications?
JM Witkin, H Shafique, JL Smith - Biochemical Pharmacology, 2024 - Elsevier
Patients with epilepsy require improved medications. Purinergic receptors were identified as
late as 1976 and are slowly emerging as potential drug targets for the discovery of …
late as 1976 and are slowly emerging as potential drug targets for the discovery of …
Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
FM Garofalo, ML Sbaraglini… - Future Medicinal …, 2023 - Taylor & Francis
Background: New hybrid compounds were synthesized by linking the valproic acid (VPA)
structure with other anticonvulsant/anti-inflammatory scaffolds. Materials & methods: The …
structure with other anticonvulsant/anti-inflammatory scaffolds. Materials & methods: The …