Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

New ideas about atrial fibrillation 50 years on

S Nattel - Nature, 2002 - nature.com
Atrial fibrillation is a condition in which control of heart rhythm is taken away from the normal
sinus node pacemaker by rapid activity in different areas within the upper chambers (atria) of …

Deep phenoty** of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes

L Cyganek, M Tiburcy, K Sekeres, K Gerstenberg… - JCI …, 2018 - pmc.ncbi.nlm.nih.gov
Generation of homogeneous populations of subtype-specific cardiomyocytes (CMs) derived
from human induced pluripotent stem cells (iPSCs) and their comprehensive phenoty** is …

Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model

M Courtemanche, RJ Ramirez… - American Journal of …, 1998 - journals.physiology.org
The mechanisms underlying many important properties of the human atrial action potential
(AP) are poorly understood. Using specific formulations of the K+, Na+, and Ca2+ currents …

Voltage-gated potassium channels as therapeutic targets

H Wulff, NA Castle, LA Pardo - Nature reviews Drug discovery, 2009 - nature.com
The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

Molecular physiology of cardiac repolarization

JM Nerbonne, RS Kass - Physiological reviews, 2005 - journals.physiology.org
The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

4-Thiazolidinones: the advances continue…

AC Tripathi, SJ Gupta, GN Fatima, PK Sonar… - European Journal of …, 2014 - Elsevier
The diversity in the biological response of 4-thiazolidinones has attracted the attention of
many researchers to explore this framework for its potential. It is, therefore, of prime …

Ion channels in the heart

DC Bartos, E Grandi… - Comprehensive …, 2015 - pmc.ncbi.nlm.nih.gov
Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

HD Devalla, V Schwach, JW Ford, JT Milnes… - EMBO molecular …, 2015 - embopress.org
Drugs targeting atrial‐specific ion channels, Kv1. 5 or Kir3. 1/3.4, are being developed as
new therapeutic strategies for atrial fibrillation. However, current preclinical studies carried …

Cardiac ionic currents and acute ischemia: from channels to arrhythmias

E Carmeliet - Physiological reviews, 1999 - journals.physiology.org
The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …