Peptidomics

R Hellinger, A Sigurdsson, W Wu… - Nature Reviews …, 2023 - nature.com
Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …

New software tools, databases, and resources in metabolomics: Updates from 2020

BB Misra - Metabolomics, 2021 - Springer
Background Precision medicine, space exploration, drug discovery to characterization of
dark chemical space of habitats and organisms, metabolomics takes a centre stage in …

Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …

SP Gaudêncio, E Bayram, L Lukić Bilela, M Cueto… - Marine drugs, 2023 - mdpi.com
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

Fungal endophytes: Microfactories of novel bioactive compounds with therapeutic interventions; A comprehensive review on the biotechnological developments in the …

A Gupta, V Meshram, M Gupta, S Goyal, KA Qureshi… - Biomolecules, 2023 - mdpi.com
The seminal discovery of paclitaxel from endophytic fungus Taxomyces andreanae was a
milestone in recognizing the immense potential of endophytic fungi as prolific producers of …

Machine learning-assisted structure annotation of natural products based on MS and NMR data

G Hu, M Qiu - Natural Product Reports, 2023 - pubs.rsc.org
Covering: up to March 2023Machine learning (ML) has emerged as a popular tool for
analyzing the structures of natural products (NPs). This review presents a summary of the …

The year 2020 in natural product bioinformatics: an overview of the latest tools and databases

MH Medema - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2020 Bioinformatic approaches to document and analyse chemical structures,
biosynthetic gene clusters and analytical data play an important role in the study of natural …

Artificial intelligence-guided discovery of anticancer lead compounds from plants and associated microorganisms

G Li, P Lin, K Wang, CC Gu, S Kusari - Trends in Cancer, 2022 - cell.com
Plants and associated microorganisms are essential sources of natural products against
human cancer diseases, partly exemplified by plant-derived anticancer drugs such as Taxol …

The Natural Products Atlas 3.0: extending the database of microbially derived natural products

EF Poynton, JA van Santen, M Pin… - Nucleic Acids …, 2025 - academic.oup.com
Abstract The Natural Products Atlas is a database of microbially derived natural products
that contains structures, producing organism taxonomy, biosynthetic and chemical ontology …

Computational genomic identification and functional reconstitution of plant natural product biosynthetic pathways

MH Medema, A Osbourn - Natural product reports, 2016 - pubs.rsc.org
Covering: 2003 to 2016 The last decade has seen the first major discoveries regarding the
genomic basis of plant natural product biosynthetic pathways. Four key computationally …

Exploring the Darobactin Class of Antibiotics: A Comprehensive Review from Discovery to Recent Advancements

A Dutta, P Sharma, D Dass… - ACS Infectious …, 2024 - ACS Publications
The prevalence of antimicrobial resistance in Gram-negative bacteria poses a greater
challenge due to their intrinsic resistance to many antibiotics. Recently, darobactins have …