Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Many biological processes are executed and regulated through the molecular interactions of
proteins and nucleic acids. Proximity labeling (PL) is a technology for tagging the …

This protocol describes the use of TurboID and split-TurboID in proximity labeling
applications for map** protein–protein interactions and subcellular proteomes in live …

Venetoclax-based therapy can induce responses in approximately 70% of older previously
untreated patients with acute myeloid leukemia (AML). However, up-front resistance as well …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Leukemia
stem cells (LSCs) drive the initiation and perpetuation of AML, are quantifiably associated …

The global diversity of fungi has been estimated between 2 to 11 million species, of which
only about 155 000 have been named. Most fungi are invisible to the unaided eye, but they …

Venetoclax with azacitidine (ven/aza) has emerged as a promising treatment regimen for
acute myeloid leukemia (AML), with a high percentage of clinical remissions in newly …

In this study we interrogated the metabolome of human acute myeloid leukemia (AML) stem
cells to elucidate properties relevant to therapeutic intervention. We demonstrate that amino …

Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be
enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in …

Perturbation of mitochondrial function can trigger a host of cellular responses that seek to
restore cellular metabolism, cytosolic proteostasis, and redox homeostasis. In some cases …