The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …

Atrial fibrillation (AF)—the most common arrhythmia—significantly increases the risk of
stroke and heart failure. Although catheter ablation can restore normal heart rhythms …

Aims The mechanisms underlying persistent atrial fibrillation (AF) in patients with atrial
fibrosis are poorly understood. The goal of this study was to use patient-derived atrial …

Ventricular arrhythmias are among the most severe complications of heart disease and can
result in sudden cardiac death. Patients at risk currently receive implantable defibrillators …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Background—Accurate knowledge of the human atrial fibrous structure is paramount in
understanding the mechanisms of atrial electric function in health and disease. Thus far …

The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …

Background: Pulmonary vein isolation (PVI) is an effective treatment strategy for patients
with atrial fibrillation (AF), but many experience AF recurrence and require repeat ablation …

Integrating spatial information about atrial physiology and anatomy in a single patient from
multimodal datasets, as well as generalizing these data across patients, requires a common …