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High-resolution native mass spectrometry
Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
Mass spectrometry-based protein footprinting for higher-order structure analysis: fundamentals and applications
Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …
functions. Understanding the complexities of protein higher-order structures and dynamics …
Protein–small molecule interactions in native mass spectrometry
Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …
scientific methodologies to occasion therapeutic advances. Although established …
Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment
The tumor microenvironment is crucial for the growth of cancer cells, triggering particular
biochemical and physiological changes, which frequently influence the outcome of …
biochemical and physiological changes, which frequently influence the outcome of …
Rapid online buffer exchange for screening of proteins, protein complexes and cell lysates by native mass spectrometry
It is important to assess the identity and purity of proteins and protein complexes during and
after protein purification to ensure that samples are of sufficient quality for further …
after protein purification to ensure that samples are of sufficient quality for further …
Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
Studying protein structure and function by native separation–mass spectrometry
Alterations in protein structure may have profound effects on biological function. Analytical
techniques that permit characterization of proteins while maintaining their conformational …
techniques that permit characterization of proteins while maintaining their conformational …
Experimental carbonic anhydrase inhibitors for the treatment of hypoxic tumors
Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) isoforms IX and XII are overexpressed in
many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation …
many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation …
Approaches to heterogeneity in native mass spectrometry
Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …
composition, and stoichiometry of biomolecules and their complexes from solution after they …
On the chemistry of aqueous ammonium acetate droplets during native electrospray ionization mass spectrometry
Ammonium acetate (NH4Ac) is a widely used solvent additive in native electrospray
ionization (ESI) mass spectrometry. NH4Ac can undergo proton transfer to form ammonia …
ionization (ESI) mass spectrometry. NH4Ac can undergo proton transfer to form ammonia …