Bone development and bone remodelling during adult life are highly anabolic processes
requiring an adequate supply of oxygen and nutrients. Bone-forming osteoblasts and bone …

Nutrition affects all physiological processes including those linked to the development and
function of our immune system. Here, we discuss recent evidence and emerging concepts …

To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we
created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride …

Bone marrow adipose tissue (BMAT) comprises> 10% of total adipose mass, yet unlike
white or brown adipose tissues (WAT or BAT) its metabolic functions remain unclear. Herein …

Mammals evolved in the face of fluctuating food availability. How the immune system adapts
to transient nutritional stress remains poorly understood. Here, we show that memory T cells …

The skeleton is diverse in its functions, which include mechanical support, movement, blood
cell production, mineral storage and endocrine regulation. This multifaceted role is achieved …

Most adipocytes exist in discrete depots throughout the body, notably in well-defined white
and brown adipose tissues. However, adipocytes also reside within specialized niches, of …

BM adipocytes (BMAd) are a unique cell population derived from BM mesenchymal
progenitors and marrow adipogenic lineage precursors. Although they have long been …

Under caloric restriction, bone marrow adipocytes (BM-Ads) do not decrease in size
compared to white adipocytes, suggesting they harbor unique metabolic properties. We …

The presence of adipocytes in mammalian bone marrow (BM) has been recognized
histologically for decades, yet, until recently, these cells have received little attention from …