T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Preclinical studies of the T cell growth factor activity of IL-2 resulted in this cytokine
becoming the first immunotherapy to be approved nearly 30 years ago by the US Food and …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …

Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …

Rheumatoid arthritis (RA) is one of the most common immune mediated inflammatory
diseases. People with rheumatoid arthritis present with pain, swelling, and stiffness that …

Psoriasis is a chronic inflammatory disease with a strong genetic component that can be
triggered by environmental factors. Disease pathogenesis is mainly driven by type 1 and …

Summary Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and
immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) …