Ninety per cent of the world's data have been generated in the last 5 years (Machine
learning: the power and promise of computers that learn by example. Report no. DES4702 …

Recent experimental developments in genome-wide RNA quantification hold considerable
promise for systems biology. However, rigorously probing the biology of living cells requires …

We perform a thorough analysis of RNA velocity methods, with a view towards
understanding the suitability of the various assumptions underlying popular …

The shoot apical meristem allows for reiterative formation of new aerial structures throughout
the life cycle of a plant. We use single-cell RNA sequencing to define the cellular taxonomy …

While single-cell gene expression experiments present new challenges for data processing,
the cell-to-cell variability observed also reveals statistical relationships that can be used by …

Major computational challenges exist in relation to the collection, curation, processing and
analysis of large genomic and imaging datasets, as well as the simulation of larger and …

Single-cell omics is transforming our understanding of cell biology and disease, yet the
systems-level analysis and interpretation of single-cell data faces many challenges. In this …

BACKGROUND The birth, death, and diversification of individuals are events that drive
biological processes across all scales. This is true whether the individuals in question …

INTRODUCTION Recent advances in lineage tracking using DNA-based barcoding
technologies have provided new insights into the developmental dynamics of cell …

The Waddington epigenetic landscape has become an iconic representation of the cellular
differentiation process. Recent single-cell transcriptomic data provide new opportunities for …