Hidden role of microglia during neurodegenerative disorders and neurocritical care: A mitochondrial perspective
X Wang, J Hu, S **e, W Li, H Zhang, L Huang… - International …, 2024 - Elsevier
The incidence of aging-related neurodegenerative disorders and neurocritical care diseases
is increasing worldwide. Microglia, the main inflammatory cells in the brain, could be …
is increasing worldwide. Microglia, the main inflammatory cells in the brain, could be …
[HTML][HTML] Novel insights into the role of TREM2 in cerebrovascular diseases
WA Awuah, A Ben-Jaafar, JSH Kong, V Sankar… - Brain Research, 2024 - Elsevier
Cerebrovascular diseases (CVDs) include conditions such as stroke, cerebral amyloid
angiopathy (CAA) and cerebral small vessel disease (CSVD), which contribute significantly …
angiopathy (CAA) and cerebral small vessel disease (CSVD), which contribute significantly …
[HTML][HTML] Macropinocytosis is the principal uptake mechanism of antigen-presenting cells for allergen-specific virus-like nanoparticles
A Kraus, B Kratzer, ANA Sehgal, D Trapin, M Khan… - Vaccines, 2024 - mdpi.com
Virus-like nanoparticles (VNP) are regarded as efficient vaccination platforms and have
proven to be useful for the non-anaphylactogenic delivery of allergen-specific …
proven to be useful for the non-anaphylactogenic delivery of allergen-specific …
Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke
Neuronal ferroptosis plays a key role in neurologic deficits post intracerebral hemorrhage
(ICH). However, the endogenous regulation of rescuing ferroptotic neurons is largely …
(ICH). However, the endogenous regulation of rescuing ferroptotic neurons is largely …
Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis
X Kong, W Lyu, X Lin, C Lin, H Feng, L Xu… - Journal of …, 2024 - Springer
Background Postoperative cognitive dysfunction (POCD) is a common neurological
complication of anesthesia and surgery in aging individuals. Neuroinflammation has been …
complication of anesthesia and surgery in aging individuals. Neuroinflammation has been …
Accumulated BCAAs and BCKAs contribute to the HFD-induced deterioration of Alzheimer's disease via a dysfunctional TREM2-related reduction in microglial β …
Y Yang, G Shi, Y Ge, S Huang, N Cui, L Tan… - Journal of …, 2024 - Springer
A high-fat diet (HFD) induces obesity and insulin resistance, which may exacerbate amyloid-
β peptide (Aβ) pathology during Alzheimer's disease (AD) progression. Branched-chain …
β peptide (Aβ) pathology during Alzheimer's disease (AD) progression. Branched-chain …
[HTML][HTML] The anti-inflammatory effects of itaconate and its derivatives in neurological disorders
X Kong, L Xu, Z Mou, W Lyu, K Shan, L Wang… - Cytokine & Growth …, 2024 - Elsevier
Almost 16% of the global population is affected by neurological disorders, including
neurodegenerative and cerebral neuroimmune diseases, triggered by acute or chronic …
neurodegenerative and cerebral neuroimmune diseases, triggered by acute or chronic …
Efferocytosis: the resolution of inflammation in cardiovascular and cerebrovascular disease
B Zhang, Y Zou, Z Yuan, K Jiang, Z Zhang… - Frontiers in …, 2024 - frontiersin.org
Cardiovascular and cerebrovascular diseases have surpassed cancer as significant global
health challenges, which mainly include atherosclerosis, myocardial infarction, hemorrhagic …
health challenges, which mainly include atherosclerosis, myocardial infarction, hemorrhagic …
Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide‐Induced Lung Injury in Obesity
J Ma, Y Ao, Z Yue, Z Wang, X Hou, H Li… - Advanced …, 2025 - Wiley Online Library
To investigate the mechanisms behind the worsening of acute lung injury (ALI) in obesity,
transcriptomic sequencing is performed, and significantly reduced mRNA levels of Aconitate …
transcriptomic sequencing is performed, and significantly reduced mRNA levels of Aconitate …
Activation of Nrf2 Pathway by 4-Octyl Itaconate Enhances Donor Lung Function in Cold Preservation Settings
X Gao, M Tang, J Li, J Ma, Z Liu, W Liu - 2024 - researchsquare.com
Background: Lung transplantation is the primary treatment for end-stage lung diseases.
However, ischemia-reperfusion injury (IRI) significantly impacts transplant outcomes. 4-Octyl …
However, ischemia-reperfusion injury (IRI) significantly impacts transplant outcomes. 4-Octyl …