People with obesity commonly face a pervasive, resilient form of social stigma. They are
often subject to discrimination in the workplace as well as in educational and healthcare …

Evidence has accumulated to demonstrate the pervasiveness, impact and implications of
weight stigma. As such, there is a need for concerted efforts to address weight stigma and …

Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …

Abstract Mendelian randomization-Egger (MR-Egger) is an analysis method for Mendelian
randomization using summarized genetic data. MR-Egger consists of three parts:(1) a test …

MendelianRandomization is a software package for the R open-source software
environment that performs Mendelian randomization analyses using summarized data. The …

Objectives Researchers often perform arbitrary outcome transformations to fulfill the
normality assumption of a linear regression model. This commentary explains and illustrates …

Abstract Background The triglyceride-glucose (TyG) index and triglyceride to high-density
lipoprotein cholesterol (TG/HDL-C) ratio, two simple surrogate indicators of insulin …

Estimates from Mendelian randomization studies of unrelated individuals can be biased due
to uncontrolled confounding from familial effects. Here we describe methods for within-family …

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

The UK Biobank is a prospective study of 502,543 individuals, combining extensive
phenotypic and genotypic data with streamlined access for researchers around the world …