Colorectal cancer (CRC) represents approximately 10% of all cancers and is the second
most common cause of cancer deaths. Initial clinical presentation as metastatic CRC …

Next-generation sequencing (NGS) allows sequencing of a high number of nucleotides in a
short time frame at an affordable cost. While this technology has been widely implemented …

Colorectal cancer (CRC) is the third most common cancer worldwide, with 1.1 million new
cases per year, and is the second leading cause of cancer death. 1 CRC occurs more …

Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second
leading cause of cancer death in the United States. Management of disseminated metastatic …

Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Medical imaging can assess the tumor and its environment in their entirety, which makes it
suitable for monitoring the temporal and spatial characteristics of the tumor. Progress in …

Remarkable progress has been made in the development of biomarker-driven targeted
therapies for patients with multiple cancer types, including melanoma, breast and lung …

Patient-derived organoids (PDOs) recapitulate tumor architecture, contain cancer stem cells
and have predictive value supporting personalized medicine. Here we describe a large …

Abstract RAS mutations (HRAS, NRAS, and KRAS) are among the most common
oncogenes, and around 19% of patients with cancer harbor RAS mutations. Cells harboring …

Background Advancements in the field of precision medicine have prompted the European
Society for Medical Oncology (ESMO) Precision Medicine Working Group to update the …