Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …

Immune check point blockade therapy has revolutionized the standard of cancer treatment
and is credited with producing remarkable tumor remissions and increase in overall survival …

The T cell co-stimulatory molecule OX40 and its cognate ligand OX40L have attracted broad
research interest as a therapeutic target in T cell-mediated diseases. Accumulating …

Immunotherapies like the adoptive transfer of gene-engineered T cells and immune
checkpoint inhibitors are novel therapeutic modalities for advanced cancers. However, some …

Single-cell sequencing technologies have noteworthily improved our understanding of the
genetic map and molecular characteristics of bladder cancer (BC). Here we identify CD39 as …

Immune checkpoint inhibitors have changed the treatment landscape for various
malignancies; however, their benefit is limited to a subset of patients. The immune …

Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …

Antigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptors
(CARs) are a potent immunosuppressive cellular therapy in multiple disease models and …

Prosurvival tumor necrosis factor receptor (TNFR) superfamily (TNFRSF) members on T
cells, including 4-1BB, CD27, GITR, and OX40, support T cell accumulation during clonal …

Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown etiology with limited
treatment options. The role of the immune system in IPF has received increasing attention …