In previous studies, using polymerase chain reaction amplification of HIV-1 genes directly
from pathologic tissues of children who died with AIDS encephalopathy, we showed that the …

The Human Immunodeficiency Virus-1 (HIV-1) Nef protein that was originally identified as a
viral negative factor is a 27kDa myristoylated protein. However, this so called dispensable …

The nef gene product of human immunodeficiency virus type 1 (HIV-1) is important for the
induction of AIDS, and key to its function is its ability to manipulate T-cell function by …

CpG dinucleotides are suppressed in the genomes of many vertebrate RNA viruses,
including HIV-1. The cellular antiviral protein ZAP (zinc finger antiviral protein) binds CpGs …

The Nef protein of primate immunodeficiency viruses plays an important role in the
pathogenesis of acquired immunodeficiency syndrome (AIDS)[1, 2]. The interaction of Nef …

The net gene is unique to the primate lentiviruses. Over the last 5 years it has become clear
that nefplays a key role in the pathogenesis of AIDS and this has led to a resurgence in …

Many viruses have evolved genes encoding proteins that regulate cell death by apoptosis.
The human immunodeficiency virus type 1 (HIV-1) Nef protein alters T-cell development and …

The human immunodeficiency virus-1 (HIV-1) Nef protein, originally identified as a negative
factor, has now emerged as one of the most important viral proteins necessary for viral …

We have generated recombinant influenza A viruses belonging to the H1N1 and H3N2 virus
subtypes containing an insertion of the 137 C-terminal amino acid residues of the human …

Expression of the human immunodeficiency virus (HIV) Nef protein has been linked to both
decreased cell surface expression of CD4 and an impairment of signal transduction. The …