Obesity and its associated secondary complications are active areas of investigation in
search of effective treatments. As a result of this intensified research numerous differences …

INTRODUCTION Sex differences are widespread in humans and other mammals. For
example, the distribution of height or body size is shifted upwards in males relative to …

Cancer-associated cachexia (CAC) is a complex multiple organ syndrome that significantly
contributes to reduced quality of life and increased mortality among many cancer patients. Its …

Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of
branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule …

When energy is needed, white adipose tissue (WAT) provides fatty acids (FAs) for use in
peripheral tissues via stimulation of fat cell lipolysis. FAs have been postulated to play a …

Abstract Background/Objective Insulin resistance is more prominent in men than women. If
this involves adipose tissue is unknown and was presently examined. Subjects/Methods …

Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid
accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and …

Caloric restriction (CR) is standard lifestyle therapy in obesity management. CR-induced
weight loss improves the metabolic profile of individuals with obesity. In mice, occurrence of …

Obesity-related insulin resistance (IR) may develop in multiple organs, representing various
etiologies for cardiometabolic diseases. We identified abdominal subcutaneous adipose …

Background A low-calorie diet (LCD) reduces fat mass excess, improves insulin sensitivity,
and alters adipose tissue (AT) gene expression, yet the relation with clinical outcomes …