Mediator complex (MED) is an evolutionarily conserved multiprotein, fundamental for growth
and survival of all cells. In eukaryotes, the mRNA transcription is dependent on RNA …

Since the identification of a metazoan counterpart to yeast Mediator nearly 15 years ago, a
convergent body of biochemical and molecular genetic studies have confirmed their …

Summary Monocarboxylate transporter 1 (MCT1) inhibition is thought to block tumor growth
through disruption of lactate transport and glycolysis. Here, we show MCT1 inhibition …

Lung cancer is the most common cause of cancer mortality in male and female patients in
the US. Although it is clear that tobacco smoking is a major cause of lung cancer, about half …

Triple‐negative breast cancer (TNBC) occurs in 10–15% of patients yet accounts for almost
half of all breast cancer deaths. TNBCs lack expression of estrogen and progesterone …

Background The protein AGR2 is a putative member of the protein disulfide isomerase
family and was first identified as a homolog of the Xenopus laevis gene XAG-2. AGR2 has …

Despite significant advances in biology and medicine, the incidence and mortality due to
breast cancer worldwide is still unacceptably high. Thus, there is an urgent need to discover …

Mediator (MED) is a fundamental component of the RNA polymerase II-mediated
transcription machinery. This multiprotein complex plays a pivotal role in the regulation of …

Resveratrol and pterostilbene exhibit diverse biological activities. MED28, a subunit of the
mammalian Mediator complex for transcription, was also identified as magicin, an actin …

Background Tissue microarray (TMA) data are commonly used to validate the prognostic
accuracy of tumor markers. For example, breast cancer TMA data have led to the …