Toxicology and pharmacology of synthetic organoselenium compounds: An update

CW Nogueira, NV Barbosa, JBT Rocha - Archives of Toxicology, 2021 - Springer
Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

[HTML][HTML] Selenium and selenoproteins in viral infection with potential relevance to COVID-19

J Zhang, R Saad, EW Taylor, MP Rayman - Redox biology, 2020 - Elsevier
Selenium is a trace element essential to human health largely because of its incorporation
into selenoproteins that have a wide range of protective functions. Selenium has an ongoing …

[HTML][HTML] Ebselen and analogues: pharmacological properties and synthetic strategies for their preparation

C Santi, C Scimmi, L Sancineto - Molecules, 2021 - mdpi.com
Ebselen is the leader of selenorganic compounds, and starting from its identification as
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …

Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways

GK Azad, RS Tomar - Molecular biology reports, 2014 - Springer
Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a
multifunctional compound, which catalyzes several essential reactions for the protection of …

Chemical reporters for bacterial glycans: development and applications

N Banahene, HW Kavunja, BM Swarts - Chemical reviews, 2021 - ACS Publications
Bacteria possess an extraordinary repertoire of cell envelope glycans that have critical
physiological functions. Pathogenic bacteria have glycans that are essential for growth and …

The mycobacterial cell envelope—lipids

M Jackson - Cold Spring Harbor perspectives in …, 2014 - perspectivesinmedicine.cshlp.org
Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …

Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N6-Methyladenosine-Modified RNAs

M Micaelli, A Dalle Vedove, L Cerofolini… - ACS Pharmacology & …, 2022 - ACS Publications
YTHDF proteins bind the N 6-methyladenosine (m6A)-modified mRNAs, influencing their
processing, stability, and translation. Therefore, the members of this protein family play …

Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe

M Kamariza, P Shieh, CS Ealand, JS Peters… - Science translational …, 2018 - science.org
Tuberculosis (TB) is the leading cause of death from an infectious bacterial disease. Poor
diagnostic tools to detect active disease plague TB control programs and affect patient care …

The cell envelope glycoconjugates of Mycobacterium tuberculosis

SK Angala, JM Belardinelli, E Huc-Claustre… - Critical reviews in …, 2014 - Taylor & Francis
Tuberculosis (TB) remains the second most common cause of death due to a single
infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent …

Small molecules that sabotage bacterial virulence

BK Johnson, RB Abramovitch - Trends in pharmacological sciences, 2017 - cell.com
The continued rise of antibiotic-resistant bacterial infections has motivated alternative
strategies for target discovery and treatment of infections. Antivirulence therapies function …