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The gut microbiome as a modulator of healthy ageing
The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …
communicable diseases in all age groups. Some age-linked and disease-linked …
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
CA Akdis - Nature Reviews Immunology, 2021 - nature.com
There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …
proportions and now affecting more than one billion people worldwide. These diseases are …
Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma
W Luo, J Hu, W Xu, J Dong - Frontiers in Immunology, 2022 - frontiersin.org
Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children
As the incidence of immune-mediated diseases has increased rapidly in developed
societies, there is an unmet need for novel prophylactic practices to fight against these …
societies, there is an unmet need for novel prophylactic practices to fight against these …
Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma
Growing up on a farm is associated with an asthma-protective effect, but the mechanisms
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …
Rhinitis associated with asthma is distinct from rhinitis alone: the ARIA‐MeDALL hypothesis
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …
Current understanding of the human microbiome
Our understanding of the link between the human microbiome and disease, including
obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding …
obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding …
The role of lung and gut microbiota in the pathology of asthma
Asthma is a common chronic respiratory disease affecting more than 300 million people
worldwide. Clinical features of asthma and its immunological and molecular etiology vary …
worldwide. Clinical features of asthma and its immunological and molecular etiology vary …
Soil and human health: current status and future needs
Soil influences human health in a variety of ways, with human health being linked to the
health of the soil. Historically, emphasis has been placed on the negative impacts that soils …
health of the soil. Historically, emphasis has been placed on the negative impacts that soils …
Human immune diversity: from evolution to modernity
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …