Purpose Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors
comprising various breast cancers simply defined by the absence of estrogen receptor …

The cloning of the breast cancer susceptibility genes BRCA1 and BRCA2 nearly two
decades ago helped set in motion an avalanche of research exploring how genomic …

Most common breast cancer susceptibility variants have been identified through genome-
wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease …

Genome-wide association studies (GWAS) and large-scale replication studies have
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Objectives Physical inactivity and sedentary behaviour are associated with higher breast
cancer risk in observational studies, but ascribing causality is difficult. Mendelian …

Breast cancer is a heterogeneous disease, divisible into a variable number of clinical
subtypes. A fundamental question is how many etiological classes underlie the clinical …

Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a
higher proportion occurring in younger women and women of African ancestry. The etiology …

Breast cancer is the most common cancer among women in the United States, with up to
30% of those diagnosed displaying a family history of breast cancer. To date, 18% of the …

Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic
basis, but this has not been investigated systematically by genome-wide association (GWA) …