Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Recent advances in sequencing techniques that measure nascent transcripts and that
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Promoter-proximal pausing by RNA polymerase II (Pol II) is a well-established mechanism to
control the timing, rate, and possibly the magnitude of transcriptional responses. Recent …

Over 60 bromodomains belonging to proteins with very different functions have been
identified in humans. Several of them interact with acetylated lysine residues, leading to the …

The coordinated regulation of transcriptional networks underpins cellular identity and
developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) …

Cyclin-dependent kinase 9 (CDK9) is a key transcriptional regulator and a lucrative target for
cancer treatment. Targeting CDK9 can effectively confine the hyperactivity of androgen …

Acetylation of histone is a key epigenetic modification, and contributes to many DNA-
dependent cellular processes. The bromodomain structure, which consists of approximately …

Mucosal surfaces of the human body are lined by a contiguous epithelial cell surface that
forms a barrier to aerosolized pathogens. Specialized pattern recognition receptors detect …

Expression of Pitx2 on the left side of the embryo patterns left-right (LR) organs including the
dorsal mesentery (DM), whose asymmetric cell behavior directs gut loo**. Despite the …