Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …

For children with neuroblastoma, the likelihood of cure varies widely according to age at
diagnosis, disease stage, and tumor biology. Treatments are tailored for children with this …

The international pediatric oncology community has a long history of research collaboration.
In the United States, the 2019 launch of the Children's Cancer Data Initiative puts the focus …

As the scale of biological data generation has increased, the bottleneck of research has
shifted from data generation to analysis. Researchers commonly need to build …

The biomedical research community is investing heavily in biomedical cloud platforms.
Cloud computing holds great promise for addressing challenges with big data and ensuring …

Data commons collate data with cloud computing infrastructure and commonly used
software services, tools, and applications to create biomedical resources for the large-scale …

Background Tumor-infiltrating CD8+ T cells and neoantigens are predictors of a favorable
prognosis and response to immunotherapy with checkpoint inhibitors in many types of adult …

PURPOSE There is a need for an improved understanding of clinical and biologic risk
factors in pediatric cancer to improve patient outcomes. Machine learning (ML) represents …

Pediatric cancer is a rare disease with a low annual incidence, which presents a significant
challenge in being able to collect enough data to fuel clinical discoveries. Big data registry …

Background As biological data increase, we need additional infrastructure to share them
and promote interoperability. While major effort has been put into sharing data, relatively …