Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS,
microglia play an important role in the monitoring and intervention of synaptic and neuron …

Complex and bidirectional interactions between the renin–angiotensin system (RAS) and
autonomic nervous system have been well established for cardiovascular regulation under …

The renin–angiotensin system (RAS) was initially considered to be part of the endocrine
system regulating water and electrolyte balance, systemic vascular resistance, blood …

Abstract The (pro) renin receptor ((P) RR) was first identified as a single-transmembrane
receptor in human kidneys and initially attracted attention owing to its potential role as a …

Using DOCA salt, a model that induces elevations in brain RAS activity and Ang-II signaling,
the same group has also shown that neuron-specific knockout of the (pro) renin receptor …

The sympathetic nervous system plays a critical role in the pathogenesis of hypertension.
The central nervous system (CNS) organizes the sympathetic outflow and various inputs …

Inflammation of forebrain and hindbrain nuclei controlling the sympathetic nervous system
(SNS) outflow from the brain to the periphery represents an emerging concept of the …

The extracellular domain of the (pro) renin receptor (PRR) is cleaved to produce a soluble
(pro) renin receptor (sPRR) that is detected in biological fluid and elevated under certain …

We previously reported that binding of prorenin to the (pro) renin receptor (PRR) plays a
major role in brain angiotensin II formation and the development of deoxycorticosterone …

A high-fructose diet is shown to induce salt-sensitive hypertension, but the underlying
mechanism largely remains unknown. The major goal of the present study was to test the …