Study of an inhibitory effect of plant polyphenolic compounds against digestive enzymes using bench-working experimental evidence predicted by molecular docking …

K Vyas, S Prabaker, D Prabhu, M Sakthivelu… - International Journal of …, 2024 - Elsevier
The substantial nutritional content and diversified biological activity of plant-based
nutraceuticals are due to polyphenolic chemicals. These chemicals are important and well …

Structure-based drug design, molecular dynamics simulation, ADMET, and quantum chemical studies of some thiazolinones targeting influenza neuraminidase

M Abdullahi, A Uzairu, GA Shallangwa… - Journal of …, 2023 - Taylor & Francis
The genetic mutability of the influenza virus leads to the existence of drug-resistant strains
which is dangerous, particularly with the lingering coronavirus disease (COVID-19). This …

[HTML][HTML] Synergy, Additive Effects, and Antagonism of Drugs with Plant Bioactive Compounds

N Chaachouay - Drugs and Drug Candidates, 2025 - mdpi.com
Background/Objectives: The interaction of bioactive compounds derived from plants with
drugs has become a significant area of investigation due to its potential to improve, reduce …

Discovery of new 2, 4-diaminopyrimidines derivatives as EGFRT790M kinase inhibitors: a structure-based approach with DFT calculation, drug-likeness, ADME …

MT Ibrahim, K Tabti, S Abdulsalam, AS Tahir… - Journal of Umm Al-Qura …, 2024 - Springer
Cancer of the lung is known to be the principal cause of tumour-linked mortality worldwide.
Non-small cell lung cancer (NSCLC) is the most common and lethal type of lung cancer with …

Biological activity, chemical composition, and molecular docking of Eugenia punicifolia (Kunth) DC

AM Dogara, MT Ibrahim, AA Mahmud… - Journal of Umm Al-Qura …, 2024 - Springer
There is a significant effort to explore the potential pharmacological activity of natural
products derived from plant extracts. The goal is to generate new compounds that could be …

Synthesis, fluorescence, enzymes effects, and evaluation of tetrahydroxy substituted zinc phthalocyanine as multitarget metabolic enzyme inhibitors with molecular …

DG Solğun, N Sadeghian, T Taskin-Tok… - Journal of the Iranian …, 2024 - Springer
Synthesis and properties of tetrahydroxy substituted zinc phthalocyanine is reported. UV–
Visible spectrum for the aggregation properties of the compound and fluorescence …

[PDF][PDF] Purple Tea (Camellia sinensis var. assamica) Leaves and Obesity Management: A Review of 1, 2-Di-Galloyl-4, 6-Hexahydroxydiphenoyl-β-D-Glucose's (GHG) …

AK Balasubramaniam, A Elangovan, MA Rahman… - Cureus, 2024 - cureus.com
Purple tea (Camellia sinensis var. assamica) is a distinct variety of Camellia sinensis known
for its bioactive compounds, including caffeine, catechins, and a unique compound called 1 …

Inhibitory effect of quercetin-3-O-α-rhamnoside, p-coumaric acid, phloridzin and 4-O-β-glucopyranosyl-cis-coumaric acid on rats liver microsomes cytochrome P450 …

C Ma, C Liu, M Ren, L Cui, X **, W Kang - Food and Chemical Toxicology, 2023 - Elsevier
P-coumaric acid, phloridzin, quercetin-3-O-α-rhamnoside and 4-O-β-glucopyranosyl-cis-
coumaric acid isolated in Malus micromalus Makino fruit were investigated the inhibitory …

Unveiling 1, 3-thiazine derivative as a potential neuraminidase inhibitor: molecular docking, molecular dynamics, ADMET and DFT studies

M Abdullahi, A Uzairu, GA Shallangwa, PA Mamza… - Chemistry Africa, 2023 - Springer
The influenza virus is usually influenced by genetic mutations and reassortment of its
different strains, resulting in drug resistance and pandemics. This necessitates the search …

Comparative studies on the interaction of casticin with five digestive enzymes using multi-spectroscopic methods, enzyme activities, and computational simulations

W Wang, Q Jiang, Y Sun, Y Zhang, Z Zhang… - Journal of Molecular …, 2024 - Elsevier
Casticin, which belongs to the flavonoid class, has been studied extensively due to its
interesting biological activities. α-Amylase, trypsin, α-chymotrypsin, pepsin and lipase are …