Novel therapeutic strategies for treatment of visceral leishmaniasis

K Jain, NK Jain - Drug discovery today, 2013‏ - Elsevier
Highlights•Visceral leishmaniasis is a fatal infectious disease caused by protozoan
parasite.•Current antileishmanial drugs are inefficient for treatment of leishmaniasis.•There …

[HTML][HTML] Antileishmanial activity of amphotericin B-loaded-PLGA nanoparticles: an overview

E Palma, A Pasqua, A Gagliardi, D Britti, M Fresta… - Materials, 2018‏ - mdpi.com
In recent decades, nanotechnology has made phenomenal strides in the pharmaceutical
field, favouring the improvement of the biopharmaceutical properties of many active …

Encapsulation of Citrus sinensis essential oil and R-limonene in lipid nanocarriers: A potential strategy for the treatment of leishmaniasis

JS Santos, JG Galvão, MRC Mendonça… - International Journal of …, 2024‏ - Elsevier
Leishmaniases, a group of neglected tropical diseases caused by an intracellular parasite of
the genus Leishmania, have significant impacts on global health. Current treatment options …

Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis

JL Arias, JD Unciti-Broceta, J Maceira… - Journal of Controlled …, 2015‏ - Elsevier
Targeted delivery of therapeutics is an alternative approach for the selective treatment of
infectious diseases. The surface of African trypanosomes, the causative agents of African …

Sustainable extraction and encapsulation of pink pepper oil

KS Andrade, D Poncelet, SRS Ferreira - Journal of Food Engineering, 2017‏ - Elsevier
Pink pepper (Schinus terebinthifolius R.) is a native tree from Brazilian coast and presents
important biological activities, such as antitumor, anti-inflammatory, antioxidant, among …

Nanotechnology-aided diagnosis, treatment and prevention of leishmaniasis

O Kammona, E Tsanaktsidou - International Journal of Pharmaceutics, 2021‏ - Elsevier
Leishmaniasis is a prevalent parasitic infection belonging to neglected tropical diseases. It is
caused by Leishmania protozoan parasites transmitted by sandflies and it is responsible for …

Encapsulation of the natural antioxidant aureusidin in biodegradable PLA nanoparticles

M Roussaki, A Gaitanarou, PC Diamanti… - Polymer Degradation …, 2014‏ - Elsevier
The purpose of this article was to investigate for the first time the nanoencapsulation of a
naturally-occurring flavonoid, ie aureusidin, exhibiting a variety of properties including …

Comparing the therapeutic efficacy of different amphotericin B-carrying delivery systems against visceral leishmaniasis

DVC Mendonça, VT Martins, DP Lage, DS Dias… - Experimental …, 2018‏ - Elsevier
Amphotericin B (Amp) has been well-successfully used to treat against Leishmania infection,
although high toxicity has been found in patients. In the present study, Amp was …

Multifunctional nanospheres for co-delivery of methotrexate and mild hyperthermia to colon cancer cells

SAC Lima, A Gaspar, S Reis, L Durães - Materials Science and …, 2017‏ - Elsevier
A multifunctional nanomedicine platform was designed and evaluated for efficient colon
cancer therapy by a combinatorial therapeutic approach based on a chemotherapeutic drug …

[HTML][HTML] Oral administration of buparvaquone nanostructured lipid carrier enables in vivo activity against Leishmania infantum

LM Monteiro, R Löbenberg, EJ Barbosa… - European Journal of …, 2022‏ - Elsevier
Leishmaniasis, a neglected tropical disease, is prevalent in 98 countries with the occurrence
of 1.3 million new cases annually. The conventional therapy for visceral leishmaniasis …