Neurovascular and cognitive dysfunction in hypertension: epidemiology, pathobiology, and treatment
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …
known to be associated with dementia caused by vascular factors, hypertension has more …
Biomarkers of aging
Aging Biomarker Consortium, H Bao, J Cao… - Science China Life …, 2023 - Springer
Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
White matter hyperintensity topography in Alzheimer's disease and links to cognition
Introduction White matter hyperintensities (WMH) are often described in Alzheimer's disease
(AD), but their topography and specific relationships with cognition remain unclear. Methods …
(AD), but their topography and specific relationships with cognition remain unclear. Methods …
Association of data-driven white matter hyperintensity spatial signatures with distinct cerebral small vessel disease etiologies
Background and Objectives Topographical distribution of white matter hyperintensities
(WMH) are hypothesized to vary by cerebrovascular risk factors. We used an unbiased …
(WMH) are hypothesized to vary by cerebrovascular risk factors. We used an unbiased …
The Brain Chart of Aging: machine‐learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING …
Introduction Relationships between brain atrophy patterns of typical aging and Alzheimer's
disease (AD), white matter disease, cognition, and AD neuropathology were investigated via …
disease (AD), white matter disease, cognition, and AD neuropathology were investigated via …
Frontal white matter lesions in Alzheimer's disease are associated with both small vessel disease and AD-associated cortical pathology
Cerebral white matter lesions (WML) encompass axonal loss and demyelination and are
assumed to be associated with small vessel disease (SVD)-related ischaemia. However, our …
assumed to be associated with small vessel disease (SVD)-related ischaemia. However, our …
White matter hyperintensities in Alzheimer's disease: beyond vascular contribution
White matter hyperintensities (WMH), frequently seen in older adults, are usually considered
vascular lesions, and participate in the vascular contribution to cognitive impairment and …
vascular lesions, and participate in the vascular contribution to cognitive impairment and …
White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition
Background White matter hyperintensities (WMH) are very frequent in older adults and
associated with worse cognitive performance. Little is known about the links between WMH …
associated with worse cognitive performance. Little is known about the links between WMH …
Disentangling heterogeneity in Alzheimer's disease and related dementias using data-driven methods
Brain aging is a complex process that includes atrophy, vascular injury, and a variety of age-
associated neurodegenerative pathologies, together determining an individual's course of …
associated neurodegenerative pathologies, together determining an individual's course of …
Association of regional white matter hyperintensities with longitudinal Alzheimer-like pattern of neurodegeneration in older adults
Importance Small vessel cerebrovascular disease, visualized as white matter
hyperintensities (WMH), is associated with cognitive decline and risk of clinical Alzheimer …
hyperintensities (WMH), is associated with cognitive decline and risk of clinical Alzheimer …