Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Prime editing enables the installation of virtually any combination of point mutations, small
insertions or small deletions in the DNA of living cells. A prime editing guide RNA (pegRNA) …

INTRODUCTION Obesity accounts for a substantial and growing burden of disease globally.
Body adiposity is highly heritable, and human genetic studies can lead to biological and …

Manipulation of DNA by CRISPR-Cas enzymes requires the recognition of a protospacer-
adjacent motif (PAM), limiting target site recognition to a subset of sequences. To remove …

Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

A primary goal of human genetics is to identify DNA sequence variants that influence
biomedical traits, particularly those related to the onset and progression of human disease …

Migraine affects over a billion individuals worldwide but its genetic underpinning remains
largely unknown. Here, we performed a genome-wide association study of 102,084 …

Sequence variants in the parental genomes that are not transmitted to a child (the proband)
are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a …