Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

E Schrezenmeier, T Dörner - Nature Reviews Rheumatology, 2020 - nature.com
Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and
chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus …

Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection

DN Juurlink - Cmaj, 2020 - Can Med Assoc
Both chloroquine and hydroxychloroquine interfere with ventricular repolarization, leading to
prolongation of the QTc interval and an increased risk of torsades de pointes (TdP). This …

COVID-19 as an acute inflammatory disease

RH Manjili, M Zarei, M Habibi… - The journal of immunology, 2020 - journals.aai.org
Abstract The 2019 coronavirus disease (COVID-19) pandemic caused by the virus severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has created an unprecedented …

Recommendations on screening for chloroquine and hydroxychloroquine retinopathy (2016 revision)

MF Marmor, U Kellner, TYY Lai, RB Melles, WF Mieler - Ophthalmology, 2016 - Elsevier
Background The American Academy of Ophthalmology recommendations on screening for
chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new …

Antivirals against coronaviruses: candidate drugs for SARS-CoV-2 treatment?

IA Santos, VR Grosche, FRG Bergamini… - Frontiers in …, 2020 - frontiersin.org
Coronaviruses (CoVs) are a group of viruses from the family Coronaviridae that can infect
humans and animals, causing mild to severe diseases. The ongoing pandemic of severe …

Hepatic consequences of COVID-19 infection. Lap** or biting?

P Portincasa, M Krawczyk, A Machill, F Lammert… - European journal of …, 2020 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19) starting last December in China
placed emphasis on liver involvement during infection. This review discusses the underlying …

Hydroxychloroquine blood levels predict hydroxychloroquine retinopathy

M Petri, M Elkhalifa, J Li, LS Magder… - Arthritis & …, 2020 - Wiley Online Library
Objective In 2016, the American Academy of Ophthalmology (AAO) changed the
recommended daily dose of hydroxychloroquine (HCQ) from 6.5 mg/kg to< 5 mg/kg …

COVID-19 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine clinical pharmacology

NJ White, JA Watson, RM Hoglund, XHS Chan… - PLoS …, 2020 - journals.plos.org
COVID-19 prevention and treatment: A critical analysis of chloroquine and
hydroxychloroquine clinical pharmacology | PLOS Medicine Skip to main content …

[HTML][HTML] Disease-drug and drug-drug interaction in COVID-19: Risk and assessment

D Kumar, N Trivedi - Biomedicine & Pharmacotherapy, 2021 - Elsevier
COVID-19 is announced as a global pandemic in 2020. Its mortality and morbidity rate are
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …

Pharmacogenomics of COVID-19 therapies

T Takahashi, JA Luzum, MR Nicol… - NPJ genomic …, 2020 - nature.com
A new global pandemic of coronavirus disease 2019 (COVID-19) has resulted in high
mortality and morbidity. Currently numerous drugs are under expedited investigations …