Glycosylation is one of the most prevalent posttranslational modifications that profoundly
affects the structure and functions of proteins in a wide variety of biological recognition …

During their development and administration, protein-based drugs routinely display
suboptimal therapeutic efficacies due to their poor physicochemical and pharmacological …

The investigation of biological processes by chemical methods, commonly referred to as
chemical biology, often requires chemical access to biologically relevant macromolecules …

Glycoproteins in animal cells contain a variety of glycan structures that are added co‐and/or
posttranslationally to proteins. Of over 20 different types of sugar–amino acid linkages …

1.1 Aims This review updates our original review on the synthesis of glycoproteins.(1) Its
aims, therefore, are 2-fold: to highlight, first, key developments since 2002 and, second …

Mucin-related tumor-associated carbohydrate antigens (TACAs) are important and
interesting targets for cancer vaccine therapy. However, efficient access to a library of mucin …

A high‐density coding system is essential to allow cells to communicate efficiently and
swiftly through complex surface interactions. All the structural requirements for forming a …

Aims This review is intended to update our previous discussion on the chemoenzymatic
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …

▪ Abstract Proteins have become accessible targets for chemical synthesis. The basic
strategy is to use native chemical ligation, Staudinger ligation, or other orthogonal chemical …

Mucin-type O-linked glycosylation is a fundamental post-translational modification that is
involved in a variety of important biological processes. However, the lack of chemical tools to …