Green chemistry in the synthesis of pharmaceuticals

S Kar, H Sanderson, K Roy, E Benfenati… - Chemical …, 2021‏ - ACS Publications
The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …

The broadening reach of frustrated Lewis pair chemistry

DW Stephan - Science, 2016‏ - science.org
BACKGROUND Since the work of Sabatier 100 year ago, chemists have turned almost
exclusively to metals to activate H2 by weakening or cleaving its central bond. This …

Frustrated Lewis pair chemistry: development and perspectives

DW Stephan, G Erker - Angewandte Chemie International …, 2015‏ - Wiley Online Library
Abstract Frustrated Lewis pairs (FLPs) are combinations of Lewis acids and Lewis bases in
solution that are deterred from strong adduct formation by steric and/or electronic factors …

FLP catalysis: main group hydrogenations of organic unsaturated substrates

J Lam, KM Szkop, E Mosaferi… - Chemical Society Reviews, 2019‏ - pubs.rsc.org
This article is focused on recent developments in main group mediated hydrogenation
chemistry and catalysis using “frustrated Lewis pairs”(FLPs). The broading range of …

Frustrated lewis pairs

DW Stephan - Journal of the American Chemical Society, 2015‏ - ACS Publications
The articulation of the notion of “frustrated Lewis pairs”(FLPs), which emerged from the
discovery that H2 can be reversibly activated by combinations of sterically encumbered …

Thermodynamic hydricity of transition metal hydrides

ES Wiedner, MB Chambers, CL Pitman… - Chemical …, 2016‏ - ACS Publications
Transition metal hydrides play a critical role in stoichiometric and catalytic transformations.
Knowledge of free energies for cleaving metal hydride bonds enables the prediction of …

Frustrated Lewis pairs: from concept to catalysis

DW Stephan - Accounts of chemical research, 2015‏ - ACS Publications
Conspectus Frustrated Lewis pair (FLP) chemistry has emerged in the past decade as a
strategy that enables main-group compounds to activate small molecules. This concept is …

Metallomimetic chemistry of boron

MA Légaré, C Pranckevicius, H Braunschweig - Chemical reviews, 2019‏ - ACS Publications
The study of main-group molecules that behave and react similarly to transition-metal (TM)
complexes has attracted significant interest in recent decades. Most notably, the attractive …

A unified survey of Si–H and H–H bond activation catalysed by electron-deficient boranes

M Oestreich, J Hermeke, J Mohr - Chemical Society Reviews, 2015‏ - pubs.rsc.org
The bond activation chemistry of B (C6F5) 3 and related electron-deficient boranes is
currently experiencing a renaissance due to the fascinating development of frustrated Lewis …

Frustrated Lewis pair chemistry of CO

DW Stephan - Chemical Society Reviews, 2023‏ - pubs.rsc.org
Transition metal species readily capture and react with CO as the metal can act both as an
acceptor and donor of electron density. In contrast, such a situation is less common in the …