Schizophrenia is a leading cause of global disability. Current pharmacotherapy for the
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …

Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …

Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …

The mammalian brain is composed of diverse, specialized cell populations. To
systematically ascertain and learn from these cellular specializations, we used Drop-seq to …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Background Neuronal networks in the brain include glutamatergic principal neurons and
GABAergic interneurons (GABA, γ-aminobutyric acid). The latter may be a minority cell type …

Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …