1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

BACKGROUND Organic synthetic chemistry has facilitated the production of medicines,
agrochemicals, food, polymers, dyes, and more through step-and atom-economical …

Conspectus Aromatic structures are widespread motifs throughout organic chemistry, and C–
H activation has been recognized as a major tool for enabling their sustainable and efficient …

Chalcogenide motifs are present as principal moieties in a vast array of natural products and
complex molecules. Till date, the construction of these chalcogen motifs has been restricted …

Pd (II)-catalyzed nondirected C–H functionalization of heteroarenes is a significant
challenge for the following reasons: poor reactivity of electron-deficient heterocycles and the …

We describe a palladium-catalyzed nondirected late-stage deuteration of arenes. Key
aspects include the use of D2O as a convenient and easily available deuterium source and …

Palladium-catalyzed C (sp3)–H functionalization presents an efficient strategy to construct a
variety of carbon–carbon bonds. However, application of this approach toward the …

Phenylacetylenes are key structural motifs in organic chemistry, which find widespread
applications in bioactive molecules, synthetic intermediates, functional materials, and …

We report nickel-catalyzed cyanation and hydrocyanation methods to prepare aryl nitriles
and vinyl nitriles from aryl halides and alkynes, respectively. Using inexpensive and …