The multiscale physics of cilia and flagella

W Gilpin, MS Bull, M Prakash - Nature Reviews Physics, 2020 - nature.com
Cilia and flagella are fundamental units of motion in cellular biology. These beating, hair-like
organelles share a common basic structure but maintain widely varying functions in systems …

Propulsive nanomachines: the convergent evolution of archaella, flagella and cilia

M Beeby, JL Ferreira, P Tripp, SV Albers… - FEMS microbiology …, 2020 - academic.oup.com
Echoing the repeated convergent evolution of flight and vision in large eukaryotes,
propulsive swimming motility has evolved independently in microbes in each of the three …

F-actin architecture determines the conversion of chemical energy into mechanical work

R Sakamoto, MP Murrell - Nature Communications, 2024 - nature.com
Mechanical work serves as the foundation for dynamic cellular processes, ranging from cell
division to migration. A fundamental driver of cellular mechanical work is the actin …

Asymmetric distribution and spatial switching of dynein activity generates ciliary motility

J Lin, D Nicastro - Science, 2018 - science.org
INTRODUCTION Motile cilia and flagella are highly conserved, hairlike appendages of
eukaryotic cells that propel the movement of cells or fluids. They play important roles in the …

[HTML][HTML] Structural diversity of axonemes across mammalian motile cilia

MR Leung, C Sun, J Zeng, JR Anderson, Q Niu… - Nature, 2025 - nature.com
Reproduction, development and homeostasis depend on motile cilia, whose rhythmic
beating is powered by a microtubule-based molecular machine called the axoneme …

Fallopian tube rheology regulates epithelial cell differentiation and function to enhance cilia formation and coordination

MS Abdul Halim, JM Dyson, MM Gong… - Nature …, 2024 - nature.com
The rheological properties of the extracellular fluid in the female reproductive tract vary
spatiotemporally, however, the effect on the behaviour of epithelial cells that line the tract is …

Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage

A Jain, BR Kim, W Yu, TO Moninger, PH Karp… - Proceedings of the …, 2024 - pnas.org
Apical cilia on epithelial cells defend the lung by propelling pathogens and particulates out
of the respiratory airways. Ciliated cells produce ATP that powers cilia beating by densely …

Flagellar energy costs across the tree of life

PE Schavemaker, M Lynch - elife, 2022 - elifesciences.org
Flagellar-driven motility grants unicellular organisms the ability to gather more food and
avoid predators, but the energetic costs of construction and operation of flagella are …

Ciliary central apparatus structure reveals mechanisms of microtubule patterning

M Gui, X Wang, SK Dutcher, A Brown… - Nature structural & …, 2022 - nature.com
A pair of extensively modified microtubules form the central apparatus (CA) of the axoneme
of most motile cilia, where they regulate ciliary motility. The external surfaces of both CA …

Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella

P Sartori, VF Geyer, A Scholich, F Jülicher, J Howard - Elife, 2016 - elifesciences.org
Cilia and flagella are model systems for studying how mechanical forces control
morphology. The periodic bending motion of cilia and flagella is thought to arise from …