Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation

S Nattel, D Dobrev - Nature Reviews Cardiology, 2016 - nature.com
Atrial fibrillation (AF) is an extremely prevalent arrhythmia that presents a wide range of
therapeutic challenges. AF usually begins in a self-terminating paroxysmal form (pAF). With …

[HTML][HTML] Techniques for automated local activation time annotation and conduction velocity estimation in cardiac map**

CD Cantwell, CH Roney, FS Ng, JH Siggers… - Computers in biology …, 2015 - Elsevier
Measurements of cardiac conduction velocity provide valuable functional and structural
insight into the initiation and perpetuation of cardiac arrhythmias, in both a clinical and …

Assessment of left atrial fibrosis by late gadolinium enhancement magnetic resonance imaging: methodology and clinical implications

J Siebermair, EG Kholmovski, N Marrouche - JACC: Clinical …, 2017 - jacc.org
Recently, studies using late gadolinium enhancement (LGE) magnetic resonance imaging
(MRI) to identify structural changes of atrial tissue have contributed significantly to …

Mechanisms underlying antiarrhythmic properties of cardioprotective agents impacting inflammation and oxidative stress

K Andelova, BS Bacova, M Sykora, P Hlivak… - International Journal of …, 2022 - mdpi.com
The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial
fibrillation remains a serious global clinical issue, with ongoing need for novel approaches …

Concurrent micro-to macro-cardiac electrophysiology in myocyte cultures and human heart slices

RA Chowdhury, KN Tzortzis, E Dupont, S Selvadurai… - Scientific reports, 2018 - nature.com
The contact cardiac electrogram is derived from the extracellular manifestation of cellular
action potentials and cell-to-cell communication. It is used to guide catheter based clinical …

[HTML][HTML] The protective role of small heat shock proteins in cardiac diseases: key role in atrial fibrillation

X Hu, DMS Van Marion, M Wiersma, D Zhang… - Cell Stress and …, 2017 - Elsevier
Atrial fibrillation (AF) is the most common tachyarrhythmia which is associated with
increased morbidity and mortality. AF usually progresses from a self-terminating paroxysmal …

[HTML][HTML] Post-operative atrial fibrillation is associated with a pre-existing structural and electrical substrate in human right atrial myocardium

JAB Zaman, L Harling, H Ashrafian, A Darzi… - International journal of …, 2016 - Elsevier
Background Post-operative atrial fibrillation (POAF) is a major health economic burden.
However, the precise mechanisms in POAF remain unclear. In other forms of AF, sites of …

Very-low-density lipoprotein of metabolic syndrome modulates gap junctions and slows cardiac conduction

HC Lee, CC Chen, WC Tsai, HT Lin, YL Shiao… - Scientific reports, 2017 - nature.com
Very-low-density lipoproteins (VLDL) is a hallmark of metabolic syndrome (MetS) and each
manifestation of MetS is related to atrial fibrillation (AF) risks. Slowed atrial conduction is a …

Characteristics of ventricular electrophysiological substrates in metabolic mice treated with empagliflozin

SJ Jhuo, IH Liu, WC Tasi, TW Chou, YH Lin… - International Journal of …, 2021 - mdpi.com
Empagliflozin (EMPA) is a sodium–glucose transporter 2 (SGLT2) inhibitor that functions as
a new-generation glucose-lowering agent and has been proven to be beneficial for patients …

Local conduction velocity in the presence of late gadolinium enhancement and myocardial wall thinning: a cardiac magnetic resonance study in a swine model of …

J Jang, J Whitaker, E Leshem, LH Ngo… - Circulation …, 2019 - Am Heart Assoc
Background: Conduction velocity (CV) is an important property that contributes to the
arrhythmogenicity of the tissue substrate. The aim of this study was to investigate the …