Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐and aging‐related diseases

AG Panossian, T Efferth, AN Shikov… - Medicinal research …, 2021 - Wiley Online Library
Adaptogens comprise a category of herbal medicinal and nutritional products promoting
adaptability, resilience, and survival of living organisms in stress. The aim of this review was …

Mechanistic pathways of sex differences in cardiovascular disease

V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2017 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

[HTML][HTML] Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

MA Feitelson, A Arzumanyan, RJ Kulathinal… - Seminars in cancer …, 2015 - Elsevier
Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Potential mechanisms of bisphenol A (BPA) contributing to human disease

I Cimmino, F Fiory, G Perruolo, C Miele… - International journal of …, 2020 - mdpi.com
Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce
polycarbonate plastic, widely used in the packaging for food and drinks, medical devices …

The immune system is a natural target for estrogen action: opposing effects of estrogen in two prototypical autoimmune diseases

D Khan, S Ansar Ahmed - Frontiers in immunology, 2016 - frontiersin.org
Analogous to other physiological systems, the immune system also demonstrates
remarkable sex differences. Although the reasons for sex differences in immune responses …

G protein-coupled receptors: novel targets for drug discovery in cancer

R Lappano, M Maggiolini - Nature reviews Drug discovery, 2011 - nature.com
G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

Glyphosate induces human breast cancer cells growth via estrogen receptors

S Thongprakaisang, A Thiantanawat… - Food and chemical …, 2013 - Elsevier
Glyphosate is an active ingredient of the most widely used herbicide and it is believed to be
less toxic than other pesticides. However, several recent studies showed its potential …

Glyphosate and the key characteristics of an endocrine disruptor: A review

JP Muñoz, TC Bleak, GM Calaf - Chemosphere, 2021 - Elsevier
Glyphosate is a large-spectrum herbicide that was introduced on the market in 1974. Due to
its important impact on the crop industry, it has been significantly diversified and expanded …

Estrogen receptors and endometriosis

E Chantalat, MC Valera, C Vaysse, E Noirrit… - International journal of …, 2020 - mdpi.com
Endometriosis is a frequent and chronic inflammatory disease with impacts on reproduction,
health and quality of life. This disorder is highly estrogen-dependent and the purpose of …

Estrogen signaling multiple pathways to impact gene transcription

M Marino, P Galluzzo, P Ascenzi - Current genomics, 2006 - ingentaconnect.com
Steroid hormones exert profound effects on cell growth, development, differentiation, and
homeostasis. Their effects are mediated through specific intracellular steroid receptors that …