Erratic or unpredictable response to drugs remains a challenge of modern drug therapy. An
important determinant of such interindividual differences in drug response is variability in the …

Nuclear receptors (NRs) are ligand-activated transcription factors sharing a common
evolutionary history and having similar sequence features at the protein level. Selective …

Human CYP2B6 has been thought to account for a minor portion (< 1%) of total hepatic
cytochrome P450 (CYP) content and to have a minor function in human drug metabolism …

Introduction:'Orphan'nuclear receptors belong to the nuclear receptor (NR) superfamily of
transcriptional factors. Binding of ligands to these receptors results in the recruitment of the …

Interindividual variability in cytochrome P450 3A4 (CYP3A4) is believed to be largely
heritable; however, predictive genetic factors have remained scarce. Using a candidate …

Two nuclear receptors, the pregnane X receptor (PXR) and the constitutive androstane
receptor (CAR), participate in the xenobiotic detoxification system by regulating the …

Cytochrome P450 3A (CYP3A) subfamily enzymes are involved in the metabolism of 40% of
drugs in clinical use. Twin studies have indicated that 66% of the variability in CYP3A4 …

Beyond their contribution to the metabolism of xenobiotics, cytochrome P450 (CYP)
epoxygenases are actively involved in the metabolism of endogenous substances, like …

The human drug metabolizing cytochrome P450 (CYP) 1A2, is one of the major P450
isoforms contributing by about 5–20% to the hepatic P450 pool and catalyzing oxidative …

Background: Antiretroviral therapy including HIV protease inhibitors and nonnucleoside
reverse transcriptase inhibitors can both inhibit and induce expression of cytochrome P450s …