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Exploring new perspectives in immunology
R Medzhitov, A Iwasaki - Cell, 2024 - cell.com
Several conceptual pillars form the foundation of modern immunology, including the clonal
selection theory, antigen receptor diversity, immune memory, and innate control of adaptive …
selection theory, antigen receptor diversity, immune memory, and innate control of adaptive …
Advanced technologies for the development of infectious disease vaccines
Vaccines play a critical role in the prevention of life-threatening infectious disease. However,
the development of effective vaccines against many immune-evading pathogens such as …
the development of effective vaccines against many immune-evading pathogens such as …
Tumor-targeting and activatable biomimetic nanococktails synergistically regulate immune responses for spatiotemporal immunotherapy of low immunogenic solid …
Y Cui, J Liu, L Cui, C Wei, M Xu, Z Wu, Y Guo, P Mi - Nano Today, 2024 - Elsevier
Cancer immunotherapy is generally limited by the low immunogenicity of tumor
microenvironments (TME). Thus, regulating immune responses in low immunogenic solid …
microenvironments (TME). Thus, regulating immune responses in low immunogenic solid …
Stimuli-Responsive Polymersomes: Resha** the Immunosuppressive Tumor Microenvironment
The progression of cancer involves mutations in normal cells, leading to uncontrolled
division and tissue destruction, highlighting the complexity of tumor microenvironments …
division and tissue destruction, highlighting the complexity of tumor microenvironments …
Programmable Macrophage Vesicle Based Bionic Self‐Adjuvanting Vaccine for Immunization against Monkeypox Virus
W Lin, C Shen, M Li, S Ma, C Liu, J Huang… - Advanced …, 2025 - Wiley Online Library
The emergence of monkeypox has become a global health threat after the COVID‐19
pandemic. Due to the lack of available specifically treatment against MPV, develo** an …
pandemic. Due to the lack of available specifically treatment against MPV, develo** an …
Virus-mimetic extracellular-vesicle vaccine boosts systemic and mucosal immunity via Immune Recruitment
J Li, H **ng, F Meng, T Liu, X Hong, X Han, Y Dong… - ACS …, 2024 - ACS Publications
Mucosal vaccines can prevent viruses from infecting the respiratory mucosa, rather than only
curtailing infection and protecting against the development of disease symptoms. The SARS …
curtailing infection and protecting against the development of disease symptoms. The SARS …
Chiral Intranasal Nanovaccines as Antivirals for Respiratory Syncytial Virus
This study aimed to develop an intranasal nanovaccine by combining chiral nanoparticles
with the RSV pre‐fusion protein (RSV protein) to create L‐nanovaccine (L‐Vac). The results …
with the RSV pre‐fusion protein (RSV protein) to create L‐nanovaccine (L‐Vac). The results …
Lung-specific supramolecular nanoparticles for efficient delivery of therapeutic proteins and genome editing nucleases
J Liu, Q Zheng, R Yao, M Wang - Proceedings of the National Academy of …, 2024 - pnas.org
Protein therapeutics play a critical role in treating a large variety of diseases, ranging from
infections to genetic disorders. However, their delivery to target tissues beyond the liver …
infections to genetic disorders. However, their delivery to target tissues beyond the liver …
Mitophagy-Enhanced Nanoparticle-Engineered Mitochondria Restore Homeostasis of Mitochondrial Pool for Alleviating Pulmonary Fibrosis
Pulmonary fibrosis (PF) is an interstitial lung disease tightly associated with the disruption of
mitochondrial pool homeostasis, a delicate balance influenced by functional and …
mitochondrial pool homeostasis, a delicate balance influenced by functional and …
Immunometabolic reprogramming of macrophages with inhalable CRISPR/Cas9 nanotherapeutics for acute lung injury intervention
W Huang, G Fu, Y Wang, C Chen, Y Luo, Q Yan, Y Liu… - Acta Biomaterialia, 2024 - Elsevier
Acute lung injury (ALI) represents a critical respiratory condition typified by rapid-onset lung
inflammation, contributing to elevated morbidity and mortality rates. Central to ALI …
inflammation, contributing to elevated morbidity and mortality rates. Central to ALI …