Exploring new perspectives in immunology

R Medzhitov, A Iwasaki - Cell, 2024 - cell.com
Several conceptual pillars form the foundation of modern immunology, including the clonal
selection theory, antigen receptor diversity, immune memory, and innate control of adaptive …

Advanced technologies for the development of infectious disease vaccines

A Gupta, A Rudra, K Reed, R Langer… - Nature Reviews Drug …, 2024 - nature.com
Vaccines play a critical role in the prevention of life-threatening infectious disease. However,
the development of effective vaccines against many immune-evading pathogens such as …

Tumor-targeting and activatable biomimetic nanococktails synergistically regulate immune responses for spatiotemporal immunotherapy of low immunogenic solid …

Y Cui, J Liu, L Cui, C Wei, M Xu, Z Wu, Y Guo, P Mi - Nano Today, 2024 - Elsevier
Cancer immunotherapy is generally limited by the low immunogenicity of tumor
microenvironments (TME). Thus, regulating immune responses in low immunogenic solid …

Stimuli-Responsive Polymersomes: Resha** the Immunosuppressive Tumor Microenvironment

Y Wei, X Weng, Y Wang, W Yang - Biomacromolecules, 2024 - ACS Publications
The progression of cancer involves mutations in normal cells, leading to uncontrolled
division and tissue destruction, highlighting the complexity of tumor microenvironments …

Programmable Macrophage Vesicle Based Bionic Self‐Adjuvanting Vaccine for Immunization against Monkeypox Virus

W Lin, C Shen, M Li, S Ma, C Liu, J Huang… - Advanced …, 2025 - Wiley Online Library
The emergence of monkeypox has become a global health threat after the COVID‐19
pandemic. Due to the lack of available specifically treatment against MPV, develo** an …

Virus-mimetic extracellular-vesicle vaccine boosts systemic and mucosal immunity via Immune Recruitment

J Li, H **ng, F Meng, T Liu, X Hong, X Han, Y Dong… - ACS …, 2024 - ACS Publications
Mucosal vaccines can prevent viruses from infecting the respiratory mucosa, rather than only
curtailing infection and protecting against the development of disease symptoms. The SARS …

Chiral Intranasal Nanovaccines as Antivirals for Respiratory Syncytial Virus

B Shi, A Qu, Z Li, Y **ong, J Ji, L Xu, C Xu… - Advanced …, 2024 - Wiley Online Library
This study aimed to develop an intranasal nanovaccine by combining chiral nanoparticles
with the RSV pre‐fusion protein (RSV protein) to create L‐nanovaccine (L‐Vac). The results …

Lung-specific supramolecular nanoparticles for efficient delivery of therapeutic proteins and genome editing nucleases

J Liu, Q Zheng, R Yao, M Wang - Proceedings of the National Academy of …, 2024 - pnas.org
Protein therapeutics play a critical role in treating a large variety of diseases, ranging from
infections to genetic disorders. However, their delivery to target tissues beyond the liver …

Mitophagy-Enhanced Nanoparticle-Engineered Mitochondria Restore Homeostasis of Mitochondrial Pool for Alleviating Pulmonary Fibrosis

Y Wang, LF Hu, NH Liu, JS Yang, L **ng, JH Jeong… - ACS …, 2024 - ACS Publications
Pulmonary fibrosis (PF) is an interstitial lung disease tightly associated with the disruption of
mitochondrial pool homeostasis, a delicate balance influenced by functional and …

Immunometabolic reprogramming of macrophages with inhalable CRISPR/Cas9 nanotherapeutics for acute lung injury intervention

W Huang, G Fu, Y Wang, C Chen, Y Luo, Q Yan, Y Liu… - Acta Biomaterialia, 2024 - Elsevier
Acute lung injury (ALI) represents a critical respiratory condition typified by rapid-onset lung
inflammation, contributing to elevated morbidity and mortality rates. Central to ALI …