Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

Yarrowia lipolytica possesses natural and engineered traits that make it a good host for the
industrial bioproduction of chemicals, fuels, foods, and pharmaceuticals. In recent years …

Understanding the consequences of genotype for phenotype (which ranges from molecule-
level effects to whole-organism traits) is at the core of genetic diagnostics in medicine. Many …

The economy of protein production is central to cell physiology, being intimately linked with
cell division rate and cell size. Attempts to model cellular physiology are limited by the …

The classical genetic approach for exploring biological pathways typically begins by
identifying mutations that cause a phenotype of interest. Overexpression or misexpression of …

Multiple human diseases are associated with a liquid-to-solid phase transition resulting in
the formation of amyloid fibers or protein aggregates. Here, we present an alternative …

The identification of untranslated regions, introns, and coding regions within an organism
remains challenging. We developed a quantitative sequencing-based method called RNA …

Epistasis, or interactions between genes, has long been recognized as fundamentally
important to understanding the structure and function of genetic pathways and the …

Fungal species have dynamic genomes and often exhibit genomic plasticity in response to
stress. This genome plasticity often comes with phenotypic consequences that affect fitness …

Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …