Accelerated aging: prediction of chemical stability of pharmaceuticals
KC Waterman, RC Adami - International Journal of Pharmaceutics, 2005 - Elsevier
Methods of rapidly and accurately assessing the chemical stability of pharmaceutical
dosage forms are reviewed with respect to the major degradation mechanisms generally …
dosage forms are reviewed with respect to the major degradation mechanisms generally …
Reactive impurities in excipients: profiling, identification and mitigation of drug–excipient incompatibility
Y Wu, J Levons, AS Narang, K Raghavan, VM Rao - Aaps Pharmscitech, 2011 - Springer
Reactive impurities in pharmaceutical excipients could cause drug product instability,
leading to decreased product performance, loss in potency, and/or formation of potentially …
leading to decreased product performance, loss in potency, and/or formation of potentially …
MAP-box: a novel, low-cost and easy-to-fabricate 3D-printed box for the storage and transportation of dissolving microneedle array patches
QK Anjani, Á Cárcamo-Martínez, LAH Wardoyo… - Drug Delivery and …, 2024 - Springer
Research on the use of microarray patches (MAPs) has progressed at an unprecedented
rate over the years, leading to the development of many novel drug delivery systems. As the …
rate over the years, leading to the development of many novel drug delivery systems. As the …
Moisture sorption by polymeric excipients commonly used in amorphous solid dispersion and its effect on glass transition temperature: I. Polyvinylpyrrolidone and …
NG Patel, ATM Serajuddin - International Journal of Pharmaceutics, 2022 - Elsevier
Moisture plays a critical role in the stability of amorphous solid dispersions (ASD) as it can
lower the glass transition temperature (T g) and thereby increase molecular mobility …
lower the glass transition temperature (T g) and thereby increase molecular mobility …
Impact of excipient interactions on solid dosage form stability
AS Narang, D Desai, S Badawy - … in formulation design and drug delivery, 2015 - Springer
Drug-excipient interactions in solid dosage forms can affect drug product stability in physical
aspects such as organoleptic changes and dissolution slowdown, or chemically by causing …
aspects such as organoleptic changes and dissolution slowdown, or chemically by causing …
The application of the accelerated stability assessment program (ASAP) to quality by design (QbD) for drug product stability
KC Waterman - AAPS PharmSciTech, 2011 - Springer
An isoconversion paradigm, where times in different temperature and humidity-controlled
stability chambers are set to provide a fixed degradant level, is shown to compensate for the …
stability chambers are set to provide a fixed degradant level, is shown to compensate for the …
Package selection for moisture protection for solid, oral drug products
KC Waterman, BC MacDonald - Journal of pharmaceutical sciences, 2010 - Elsevier
This review describes how best to select the appropriate packaging options for solid, oral
drug products based on both chemical and physical stability, with respect to moisture …
drug products based on both chemical and physical stability, with respect to moisture …
Moisture and oxygen barrier properties of glass, PET and HDPE bottles for pharmaceutical products
The purpose of this study was to evaluate the influence of the material and volume/different
finish diameters in the moisture and oxygen barrier properties for bottles for pharmaceutical …
finish diameters in the moisture and oxygen barrier properties for bottles for pharmaceutical …
Viscoelastic behavior of HDPE polymer using tensile and compressive loading
R Elleuch, W Taktak - Journal of Materials Engineering and Performance, 2006 - Springer
Large containers for liquids, exposed to different static loadings, are mainly made of high-
density polyethylene (HDPE). The viscoelastic response of HDPE under long-term tensile …
density polyethylene (HDPE). The viscoelastic response of HDPE under long-term tensile …
Dual-functionalised shellac nanocarriers give a super-boost of the antimicrobial action of berberine
We have developed highly efficient antimicrobial nanocarriers for berberine (BRB) based on
shellac nanoparticles (NPs) which were surface-functionalised with a surface active …
shellac nanoparticles (NPs) which were surface-functionalised with a surface active …