Dendritic-cell interactions with HIV: infection and viral dissemination
Dendritic cells (DCs) are crucial for the generation and the regulation of adaptive immunity.
Because DCs have a pivotal role in marshalling immune responses, HIV has evolved ways …
Because DCs have a pivotal role in marshalling immune responses, HIV has evolved ways …
Inhibiting sexual transmission of HIV-1 infection
RJ Shattock, JP Moore - Nature Reviews Microbiology, 2003 - nature.com
The worldwide infection rate for HIV-1 is estimated to be 14,000 per day, but only now, more
than 20 years into the epidemic, are the immediate events between exposure to infectious …
than 20 years into the epidemic, are the immediate events between exposure to infectious …
Langerin is a natural barrier to HIV-1 transmission by Langerhans cells
L de Witte, A Nabatov, M Pion, D Fluitsma… - Nature medicine, 2007 - nature.com
Abstract Human immunodeficiency virus-1 (HIV-1) is primarily transmitted sexually. Dendritic
cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC …
cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC …
Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer
PY Pan, G Ma, KJ Weber, J Ozao-Choy, G Wang, B Yin… - Cancer research, 2010 - AACR
Immune tolerance to tumors is often associated with accumulation of myeloid-derived
suppressor cells (MDSC) and an increase in the number of T-regulatory cells (Treg). In …
suppressor cells (MDSC) and an increase in the number of T-regulatory cells (Treg). In …
The CCR5 and CXCR4 coreceptors—central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection
JP Moore, SG Kitchen, P Pugach… - AIDS research and human …, 2004 - liebertpub.com
In this review, we will discuss what is known, what is suspected, and what still remains
obscure about the central role played by coreceptor expression and usage in the …
obscure about the central role played by coreceptor expression and usage in the …
Bottlenecks in HIV-1 transmission: insights from the study of founder viruses
HIV-1 infection typically results from the transmission of a single viral variant, the
transmitted/founder (T/F) virus. Studies of these HIV-1 variants provide critical information …
transmitted/founder (T/F) virus. Studies of these HIV-1 variants provide critical information …
Human dendritic cell subsets, ontogeny, and impact on HIV infection
JW Rhodes, O Tong, AN Harman… - Frontiers in …, 2019 - frontiersin.org
Dendritic cells (DCs) play important roles in orchestrating host immunity against invading
pathogens, representing one of the first responders to infection by mucosal invaders. From …
pathogens, representing one of the first responders to infection by mucosal invaders. From …
Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells
SG Turville, JJ Santos, I Frank, PU Cameron… - Blood, 2004 - ashpublications.org
HIV-1 subverts antigen processing in dendritic cells (DCs) resulting in viral uptake, infection,
and transfer to T cells. Although DCs bound monomeric gp120 and HIV-1 similarly, virus …
and transfer to T cells. Although DCs bound monomeric gp120 and HIV-1 similarly, virus …
HIV-1 latency in monocytes/macrophages
Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the
monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T …
monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T …
Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5
MM Lederman, RS Veazey, R Offord, DE Mosier… - Science, 2004 - science.org
Topical agents, such as microbicides, that can protect against human immunodeficiency
virus (HIV) transmission are urgently needed. Using a chimeric simian/human …
virus (HIV) transmission are urgently needed. Using a chimeric simian/human …