Nanopore DNA sequencing technologies and their applications towards single-molecule proteomics

A Dorey, S Howorka - Nature chemistry, 2024 - nature.com
Sequencing of nucleic acids with nanopores has emerged as a powerful tool offering rapid
readout, high accuracy, low cost and portability. This label-free method for sequencing at the …

[HTML][HTML] Exosome-based liquid biopsies in cancer: opportunities and challenges

W Yu, J Hurley, D Roberts, SK Chakrabortty… - Annals of …, 2021 - Elsevier
Liquid biopsy in cancer has gained momentum in clinical research and is experiencing a
boom for a variety of applications. There are significant efforts to utilize liquid biopsies in …

The new era of high-throughput nanoelectrochemistry

X Xu, D Valavanis, P Ciocci, S Confederat… - Analytical …, 2023 - ACS Publications
To acquire a deeper understanding of electrochemical systems requires techniques that
address nanoscale aspects of electrochemistry, inter alia, the detection and analysis of …

Functional nanomaterials and nanostructures enhancing electrochemical biosensors and lab-on-a-chip performances: recent progress, applications, and future …

N Wongkaew, M Simsek, C Griesche… - Chemical …, 2018 - ACS Publications
Electrochemical biosensors and associated lab-on-a-chip devices are the analytical system
of choice when rapid and on-site results are needed in medical diagnostics and food safety …

An introduction to nanopore sequencing: past, present, and future considerations

M MacKenzie, C Argyropoulos - Micromachines, 2023 - mdpi.com
There has been significant progress made in the field of nanopore biosensor development
and sequencing applications, which address previous limitations that restricted widespread …

Nanopore sensing

W Shi, AK Friedman, LA Baker - Analytical chemistry, 2017 - ACS Publications
Scope of the Review. Herein, we provide an up-to-date overview of the field of nanopore
sensing with emphases placed on the advances made in the most recent two years (2014 …

Real-time shape approximation and fingerprinting of single proteins using a nanopore

EC Yusko, BR Bruhn, OM Eggenberger… - Nature …, 2017 - nature.com
Established methods for characterizing proteins typically require physical or chemical
modification steps or cannot be used to examine individual molecules in solution. Ionic …

Nanopores: synergy from DNA sequencing to industrial filtration–small holes with big impact

ZS Siwy, ML Bruening, S Howorka - Chemical Society Reviews, 2023 - pubs.rsc.org
Nanopores in thin membranes play important roles in science and industry. Single
nanopores have provided a step-change in portable DNA sequencing and understanding …

Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore

F Piguet, H Ouldali, M Pastoriza-Gallego… - Nature …, 2018 - nature.com
There are still unmet needs in finding new technologies for biomedical diagnostic and
industrial applications. A technology allowing the analysis of size and sequence of short …

Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores

G Huang, K Willems, M Soskine, C Wloka… - Nature …, 2017 - nature.com
Biological nanopores are nanoscale sensors employed for high-throughput, low-cost, and
long read-length DNA sequencing applications. The analysis and sequencing of proteins …