Hemorrhage is a top cause of death after injury and is the leading cause of potentially
preventable trauma deaths. 1–3 In contrast to other causes of trauma death, such as …

Early diagnosis of haemorrhagic shock (HS) might be difficult because of compensatory
mechanisms. Clinical scoring systems aimed at predicting transfusion needs might assist in …

Background Organ failure, including acute kidney injury (AKI), is the third leading cause of
death after bleeding and brain injury in trauma patients. We sought to assess the …

Introduction Prediction of massive transfusion (MT) among trauma patients is difficult in the
early phase of trauma management. Whole-blood thromboelastometry (ROTEM®) tests …

The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism
of cancer drug resistance. They are also important in protecting normal tissue cells from …

BACKGROUND The acute coagulopathy of trauma is present in up to one third of patients by
the time of admission, and the recent CRASH-2 and MATTERs trials have focused …

Background Definitions for massive transfusion (MT) vary widely between studies,
contributing to challenges in interpretation of research findings and practice evaluation. In …

Introduction Hemorrhage is a leading cause of death among trauma patients, and is the
most common cause of preventable death after trauma. Since the advent of blood …

OBJECTIVE: To define the frequency, risk factors, and outcomes of massive transfusion in
obstetrics. METHODS: The State Inpatient Dataset for New York (1998–2007) was used to …

BACKGROUND Definitions of massive transfusion (MT), 10 or more units of packed red
blood cells (PRBCs) in 24 hours, focus on static volumes over fixed times. This arbitrary …