Hydrogels comprise a class of soft materials which are extremely useful in a number of
contexts, for example as matrix-mimetic biomaterials for applications in regenerative …

Proteins have evolved as a variable platform that provides access to molecules with diverse
shapes, sizes and functions. These features have inspired chemists for decades to seek …

Molecular dynamics (MD) simulations are widely used to study protein motions at an atomic
level of detail, but they have been limited to time scales shorter than those of many …

Characterizing the equilibrium ensemble of folding pathways, including their relative
probability, is one of the major challenges in protein folding theory today. Although this …

In this paper, we present 1, 2, 3-triazole ε2-amino acids incorporated as a dipeptide
surrogate at three positions in the sequence of a known α-helical coiled coil. Biophysical …

Recent developments in Origins of Life research have focused on substantiating the
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …

Nicotine addiction begins with high-affinity binding of nicotine to acetylcholine (ACh)
receptors in the brain. The end result is over 4,000,000 smoking-related deaths annually …

ABSTRACT A code predicting the RNA sequence that will be bound by a certain protein
based on its amino acid sequence or its structure would provide a useful tool for the design …

Discrete molecular dynamics (DMD) is a rapid sampling method used in protein folding and
aggregation studies. Until now, DMD was used to perform simulations of simplified protein …

Infrared spectroscopy has played an instrumental role in the study of a wide variety of
biological questions. However, in many cases, it is impossible or difficult to rely on the …