The upward extend of malaria collectively with the emergence of resistance against
predictable drugs has put enormous pressure on public health systems to introduce new …

Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

Polypharmacology describes the activity of compounds at multiple targets. Current research
focuses on two aspects of polypharmacology:(1) unintended polypharmacology can lead to …

Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …

1, 3, 4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …

We describe the synthesis and antimalarial activities of 1H-1, 2, 3-triazole tethered 7-
chloroquinoline-isatin hybrids. Activity against cultured parasites was dependent on the C-5 …

The biological activity of organic peroxides is usually associated with the antimalarial
properties of artemisinin and its derivatives. However, the analysis of published data …

The design and discovery of novel drug candidates are the initial and most probably the
crucial steps in the drug development process. One of the tasks of medicinal chemistry is to …

A Cu-mediated azide–alkyne cycloaddition protocol has been employed for the synthesis of
16 different triazoles to probe the antitubercular structure–activity relationships within the …

Malaria is one of the most prevalent parasitic diseases in the world. The global importance
of this disease, current vector control limitations, and the absence of an effective vaccine …