Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …

YAP and TAZ are transcriptional activators pervasively induced in several human solid
tumours and their functions in cancer cells are the focus of intense investigation. These …

ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …

Immune checkpoint blockade (ICB) has revolutionized cancer therapeutics. Desmoplastic
malignancies, such as cholangiocarcinoma (CCA), have an abundant tumor immune …

Epigenetic remodeling is essential for oncogene-induced cellular transformation and
malignancy. In contrast to histone post-translational modifications, how DNA methylation is …

Studies of the regenerative capacity of the liver have converged on the Hippo pathway, a
serine/threonine kinase cascade discovered in Drosophila and conserved from unicellular …

The transcriptional co-regulators YAP and TAZ pair primarily with the TEAD family of
transcription factors to elicit a gene expression signature that plays a prominent role in …